What is human chorionic gonadotropin (hCG)?

Human chorionic gonadotropin, or hCG, is a hormone that functions as a substitute for luteinizing hormone (LH) in the male body. When a man begins testosterone replacement therapy, his own LH production typically declines, which signals the testes to reduce testosterone and sperm production. hCG prevents this shutdown by binding to the same receptors that LH does, telling the testes to continue making testosterone and maintaining sperm output.

TRT clinics use hCG alongside testosterone injections or other delivery methods for men who want to preserve fertility or maintain testicular size during treatment. Without hCG, the testes can atrophy and sperm counts may drop significantly. By including hCG in a treatment protocol, patients can sustain both hormone levels and reproductive function. hCG is typically injected two to three times per week, and its dosage is adjusted based on patient goals and response.

The decision to use hCG depends on individual circumstances. Men planning to father children in the future, or those concerned about testicular health, are candidates for hCG therapy. Others may not need it if fertility preservation is not a priority. Providers in hormone therapy practices can assess whether hCG fits a patient's overall treatment plan.